Malaria: immunity by inheritance

Malaria remains a dangerous disease which every year kills at least 800 000 lives, and most of the victims are small children. Discovery Scottish scientists will become a new step towards freedom from disease.

Researchers from the University of the Scottish city of Edinburgh (University of Edinburgh) in experiments with laboratory mice found that offspring of females that were infected with malaria transmitted from mothers of a certain level of immunity against Plasmodium, the causative agents of malaria.

The hereditary immunity transferred from mother to offspring in a certain number of specific antibodies. This mechanism provides protection for calves from the development of malaria in the initial period of their life.

The authors also argue that the transfer of antibodies occurs in two ways: during pregnancy through the placenta and through breast milk after the birth of cubs.

The researchers studied the immune system of the offspring of female mice, which were infected with parasites, and then one group of rodents (experimental) received treatment with antimalarial drugs, and the animals in the control group therapy was not carried out.

The offspring that were born of females from the control group that is undergoing malaria without treatment, the risk of death from this disease in case of infection decreased by 75% compared to mice born to females treated with antimalarial drugs.

Thus, the transmission of antimalarial immunity from mother to offspring is less efficient if the mother took antimalarial drugs.

The authors believe that their findings can be useful in developing new strategies to combat malaria, which the who recently urged to declare a merciless war.

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