Scientists have learned to “fix” the immune system of cancer patients

Treatment of cancer patients by chemotherapy leads to a significant immunosuppression of the patient, which increases the risk of developing it infections. Doctors from the United States to restore the immune system with injections of their own T-lymphocytes of the patient.

Repeated courses of chemotherapy of patients with chronic lymphocytic leukemia (CLL) has a pronounced side effect in the form of almost complete oppression of immune system of a patient, which dramatically increases the risk of infectious diseases. For this reason, Western doctors the drug fludarabine, which is usually used in the treatment of CLL, even got an eloquent nickname “AIDS in the vial”.

On passing in these days in USA 53rd annual conference of the American society of hematologists (53rd American Society of Hematology Annual Meeting), provided an interesting report on the recovery of the immune system of the patient after treatment using fludarabine with injections of T-lymphocytes of the patient, which were obtained from him before the start of chemotherapy.
Clinical studies the method was carried out with the participation of 34 patients of the Abramson cancer Center in Pennsylvania (Penn’s Abramson Cancer Center).

Before starting chemotherapy about every CLL patient sample was allocated to healthy T cells, which were stored until the end of treatment. After that, cells were subjected to stimulation for reproduction outside the body and administered to patients.

30 days later the number of T-lymphocytes in the blood of patients increased on the average in 3 times and did not decrease over the next 90 days. The recovery of immunity was better in those patients in whom treatment with fludarabine led to a complete remission.

14 months later, two thirds of patients were in remission stage CLL.

“We have ensured that not more than four weeks after the introduction of T-lymphocytes to patients, the number of these immune cells increased to the normal parameters,” says co-author of the method Professor Stephen Shuster (Stephen Schuster).

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