The liver cells are able to suppress the immune system of the host

Researchers from Australia have discovered new properties of human liver – a discovery that may help over time to avoid taking drugs which depress the immune system, patients who received a transplant donor organ.

All patients who underwent surgery for transplantation of organs from another person (in vivo or post-mortem donor), is constantly forced to take immunosuppressants – drugs that prevent the rejection of “alien” on the immune system of the recipient.

However, for such patients, there is a new danger – even a minor cold or flu can be fatal, as the suppressed immune system cannot identify and destroy the enemy.
Scientists from the Institute of gerontology in Sydney, Australia (Centenary Institute in Sydney) found that the human liver has the ability to destroy T-cells of the immune system’s own body, special lymphocytes that are trying to destroy viruses, bacteria and foreign tissue transplanted organ.

The authors believe that their discovery may lead to drugs of new type, which do not fully suppress the immune system of the person receiving the new organ after transplantation, and will stimulate the liver to suppress only those T cells that can attack the transplanted organ.

“Now we have becomes clear and what previously inexplicable phenomenon when transplanted, such as kidneys or heart is almost always aggressive and attacked by the immune system of the recipient, and at the same time, the percentage of rejection in liver transplantation is significantly lower,” explains study leader Professor Patrick bertolino’s (Patrick Bertolino).

Leave a Reply